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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2, D-Pen5]-enkephalin or DPDPE for...

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Related Experiment Video

Updated: May 15, 2026

Synthesis of a Deuterated Standard for the Quantification of 2-Arachidonoylglycerol in Caenorhabditis elegans
14:25

Synthesis of a Deuterated Standard for the Quantification of 2-Arachidonoylglycerol in Caenorhabditis elegans

Published on: September 21, 2019

Epigenetic mechanisms and endocannabinoid signalling.

Claudio D'Addario1, Andrea Di Francesco, Mariangela Pucci

  • 1Department of Biomedical Sciences, University of Teramo, Teramo, Italy. cdaddario@unite.it

The FEBS Journal
|January 12, 2013
PubMed
Summary

The endocannabinoid system

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • The endocannabinoid system regulates numerous biological functions in health and disease.
  • Its role in cellular processes and therapeutic potential is increasingly recognized.
  • Regulatory mechanisms require further clarification.

Purpose of the Study:

  • To review the epigenetic regulation of the endocannabinoid system.
  • To explore epigenetic changes induced by endocannabinoid signaling.
  • To discuss the potential for epigenetic therapy targeting the endocannabinoid system.

Main Methods:

  • Literature review of current knowledge on epigenetics and the endocannabinoid system.
  • Analysis of epigenetic modifications (DNA methylation, histone modifications, non-coding RNAs) affecting endocannabinoid system components.

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  • Examination of studies investigating endocannabinoid signaling-induced epigenetic alterations.

    • Main Results:

    • Epigenetic mechanisms significantly influence endocannabinoid system components.
    • Endocannabinoid signaling can induce reversible epigenetic changes.
    • The interplay between epigenetics and the endocannabinoid system is complex and bidirectional.

    Conclusions:

    • Epigenetic regulation is a critical factor in understanding the endocannabinoid system's function.
    • Targeting epigenetic modifications offers potential therapeutic strategies for conditions involving the endocannabinoid system.
    • Further research is needed to fully elucidate these interactions and their therapeutic implications.