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Published on: September 16, 2022
Acid suppression therapy as a risk factor for Candida esophagitis
Kyung-Yup Kim1, Jae Young Jang, Jung-Wook Kim
1Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Hoegi-dong 1, Dongdaemoon-gu, Seoul, 130-702, South Korea.
The prevalence of Candida esophagitis (CE) is rising in Korea, with gastric acid suppression therapy identified as a significant risk factor. This study highlights the need for awareness and further investigation into CE development.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Epidemiology
Background:
- Reflux esophagitis and the use of gastric acid suppressants are increasing.
- Candida esophagitis (CE) is a growing concern in clinical practice.
Purpose of the Study:
- To determine the prevalence of CE in Korea over a five-year period.
- To identify risk factors associated with CE, particularly gastric acid suppression therapy.
Main Methods:
- Retrospective analysis of 55,314 esophagogastroduodenoscopies (2006-2010).
- Comparison of 250 CE patients with 500 matched controls (2008-2011).
- Evaluation of risk factors including gastric acid suppression, malignancy, diabetes mellitus (DM), and steroid therapy.
Main Results:
- CE prevalence was 0.35% and showed a significant annual increase (P = 0.001).
- Multivariate analysis confirmed gastric acid suppression (OR 5.11), malignancy (OR 18.68), DM (OR 2.67), and steroid therapy (OR 6.74) as significant risk factors for CE.
Conclusions:
- The incidence of Candida esophagitis in Korea is on the rise.
- Gastric acid suppression therapy is a significant risk factor contributing to the development of CE.
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