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Osteomyelitis complicating scleroderma digital ulcers.

Dilia Giuggioli1, Andreina Manfredi, Michele Colaci

  • 1Rheumatology Unit, University of Modena and Reggio Emilia, Medical School, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy. giuggioli.dilia@policlinico.mo.it

Clinical Rheumatology
|January 12, 2013
PubMed
Summary
This summary is machine-generated.

Osteomyelitis (OM) is a frequent complication of infected skin ulcers in scleroderma (SSc) patients. This study found a high prevalence of OM in SSc, primarily linked to digital ulcers.

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Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Dermatology

Background:

  • Skin ulcers are common in scleroderma (SSc), frequently leading to local infections.
  • These infections can progress to osteomyelitis (OM), affecting the underlying bone.

Purpose of the Study:

  • To investigate the prevalence of osteomyelitis (OM) in patients with scleroderma (SSc).
  • To identify the association between infected skin ulcers and OM in SSc patients.

Main Methods:

  • Retrospective analysis of 248 SSc patients.
  • Evaluation of patients with infected skin ulcers for complicating OM using clinical, laboratory, and radiological data.

Main Results:

  • Skin ulcers were present in 48% of SSc patients, predominantly digital ulcers (92%).
  • Osteomyelitis (OM) prevalence was 7.7% in the SSc cohort, invariably associated with infected digital ulcers.
  • 42% of patients with infected digital ulcers had underlying bone involvement (OM); Staphylococcus aureus and Escherichia coli were common pathogens.

Conclusions:

  • Infected digital ulcers are the primary predisposing factor for osteomyelitis (OM) in scleroderma (SSc) patients.
  • This study highlights a high prevalence of OM in SSc, emphasizing the need for vigilant management of infected digital ulcers.