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Related Concept Videos

Coulomb's Law01:30

Coulomb's Law

Experiments with electric charges have shown that if two objects each have an electric charge, they exert an electric force on each other. The magnitude of the force is linearly proportional to the net charge on each object and inversely proportional to the square of the distance between them. The direction of the force vector is along the imaginary line joining the two objects and is dictated by the signs of the charges involved.
Newton's third law applies to the Coulomb force — the force on...
Controlled-Potential Coulometry: Electrolytic Methods01:17

Controlled-Potential Coulometry: Electrolytic Methods

Controlled-potential coulometry, also known as potentiostatic coulometry, employs a three-electrode system in which the working electrode's potential is precisely regulated using a potentiostat. Platinum working electrodes are utilized for positive potentials, while mercury pool electrodes are favored for extremely negative potentials. The platinum counter electrode is separated from the analyte using a membrane or salt bridge to avoid interference in the analysis.
The chosen potential ensures...
Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism.
Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism.
Electrostatic Boundary Conditions in Dielectrics01:27

Electrostatic Boundary Conditions in Dielectrics

When an electric field passes from one homogeneous medium to another, crossing the boundary between the two mediums imparts a discontinuity in the electric field. This results in electrostatic boundary conditions that depend on the type of mediums the field propagates through.
Consider a case where both the mediums across a boundary are two different dielectric materials. Recall that the electric field and electric displacement are proportional and related through the material's permittivity.
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that include the...

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Related Experiment Video

Updated: May 15, 2026

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

Ionic Coulomb blockade in nanopores.

Matt Krems1, Massimiliano Di Ventra

  • 1Department of Physics, University of California, San Diego, La Jolla, CA 92093, USA. mkrems@physics.ucsd.edu

Journal of Physics. Condensed Matter : an Institute of Physics Journal
|January 12, 2013
PubMed
Summary
This summary is machine-generated.

Ionic Coulomb blockade occurs in nanopores due to ion-ion interactions, impeding ion flow. This phenomenon, analogous to electronic Coulomb blockade, has implications for nanopore applications.

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Last Updated: May 15, 2026

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
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08:51

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High Resolution Physical Characterization of Single Metallic Nanoparticles
09:56

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Published on: June 28, 2019

Area of Science:

  • Nanopore science
  • Physical chemistry
  • Molecular dynamics

Background:

  • Understanding ion dynamics in nanopores is crucial for advanced applications like single-molecule detection and DNA sequencing.
  • Nanopore systems offer unique environments for studying ion transport phenomena.

Purpose of the Study:

  • To investigate the phenomenon of ionic Coulomb blockade in nanopores.
  • To analyze the role of ion-ion interactions and pore capacitance in ion transport.

Main Methods:

  • Analytical modeling of ion behavior within nanopores.
  • Molecular dynamics simulations to observe ion interactions and transport.

Main Results:

  • Demonstrated the occurrence of ionic Coulomb blockade under specific conditions in nanopores.
  • Identified Coulomb repulsion between ions as the mechanism for impeding ion flow.
  • Established analogies and differences with electronic Coulomb blockade.

Conclusions:

  • Ionic Coulomb blockade is a significant phenomenon in nanopore systems.
  • The findings provide insights into controlling ion transport for technological applications.
  • Experimental detection of this phenomenon is feasible and warrants further investigation.