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Related Experiment Video

Updated: May 15, 2026

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
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Advances in breast surgery, 2002-2012.

Stephen B Edge1

  • 1Roswell Park Cancer Institute, University at Buffalo, Buffalo, New York 14263, USA. Stephen.edge@roswellpark.org

Journal of the National Comprehensive Cancer Network : JNCCN
|January 12, 2013
PubMed
Summary
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Significant advancements in breast cancer treatment, including breast-conserving therapy (BCT), have reduced mortality by 30%. Modern systemic therapies and improved surgical standards have made BCT a safe and effective option for most patients.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Clinical Trials

Background:

  • Breast cancer mortality has decreased by 30% over 40 years due to treatment advancements.
  • Clinical trials have been pivotal in refining breast cancer management strategies.
  • Early surgical approaches did not significantly improve survival compared to less invasive methods.

Purpose of the Study:

  • To review the evolution of breast cancer treatments over the past four decades.
  • To highlight the shift from radical mastectomy to breast-conserving therapy (BCT).
  • To explore recent advancements in breast surgery within the last 10 years.

Main Methods:

  • Analysis of historical and modern clinical trial data.
  • Comparison of outcomes between mastectomy and breast-conserving therapy (BCT).

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  • Evaluation of the impact of systemic therapies (endocrine and chemotherapy) and improved standards in surgery, radiation oncology, and pathology.

    • Main Results:

    • Extended surgery (local therapy) does not improve mortality over less aggressive surgery.
    • Breast-conserving therapy (BCT) offers comparable outcomes to mastectomy regarding survival.
    • Modern BCT shows a local recurrence risk of 2-5%, similar to mastectomy, largely due to systemic therapies.

    Conclusions:

    • Breast-conserving therapy (BCT) is a safe and effective option for the majority of breast cancer patients.
    • Advancements in systemic therapies and surgical techniques have significantly improved BCT outcomes.
    • Continued research and clinical trials are essential for further progress in breast cancer treatment.