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Hemodynamic changes associated with anaphylaxis in parasite-sensitized rats
R Mathison1, A D Befus, J S Davison
1Department of Medical Physiology, University of Calgary, Alberta, Canada.
The American Journal of Physiology
|April 1, 1990
Summary
Worm allergen exposure in rats triggers anaphylactic shock, altering blood flow to vital organs. The intestine is significantly impacted, while the liver may help mitigate anaphylaxis.
Area of Science:
- Immunology
- Physiology
- Parasitology
Background:
- Anaphylaxis is a severe allergic reaction that can lead to circulatory collapse.
- Nippostrongylus brasiliensis infection in rats is a model for studying helminth-induced immune responses and anaphylaxis.
Purpose of the Study:
- To investigate the microcirculatory alterations during worm allergen-induced anaphylactic shock in rats.
- To identify specific organ systems affected by anaphylaxis and their blood flow dynamics.
Main Methods:
- Rats infected with Nippostrongylus brasiliensis were challenged with worm allergen.
- Hemodynamic parameters including heart rate, mean arterial blood pressure, and cardiac output were measured.
- Regional blood flow and percent distribution of cardiac output to various tissues were assessed.
Main Results:
- Allergen challenge induced a transient decrease in heart rate, mean arterial blood pressure, and cardiac output.
- Blood flow was reduced in most tissues initially, with exceptions including kidneys, heart, and brain.
- Significant alterations in blood flow distribution were observed in organs such as the adrenals, kidneys, and intestines at later time points.
Conclusions:
- The intestine is a key organ affected by anaphylaxis in this rat model.
- The liver may play a role in the resolution or alleviation of anaphylactic responses.