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Related Experiment Videos

Ocular amyloidosis: clinical points learned from one case.

C Bene1, G Kranias

  • 1Christ Hospital, Cincinnati, OH.

Annals of Ophthalmology
|March 1, 1990
PubMed
Summary

Amyloidosis can cause unexplained vitreous opacification, delaying diagnosis. Early consideration and diagnostic tools like conjunctival biopsy are crucial for managing this rare ocular condition.

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Area of Science:

  • Ophthalmology
  • Neurology
  • Pathology

Background:

  • Bilateral vitreous opacification presents a diagnostic challenge.
  • Peripheral neuropathy can be an early indicator of systemic disease.

Observation:

  • A 72-year-old man with bilateral vitreous opacification and mild peripheral neuropathy underwent multiple vitrectomies.
  • Diagnosis of amyloidosis was confirmed post-second vitrectomy via Congo red staining of aspirate.

Findings:

  • Amyloid deposition in the vitreous humor caused the opacification.
  • Delayed diagnosis was linked to underrecognizing the significance of peripheral neuropathy.

Implications:

  • Consider amyloidosis in patients with unexplained vitreous infiltration.
  • Conjunctival biopsy may aid diagnosis.
  • Surgical removal of vitreous may reduce reopacification incidence.

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