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Updated: May 15, 2026
A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure
Published on: May 15, 2020
Vascular miRNAs after balloon angioplasty
Alberto Polimeni1, Salvatore De Rosa, Ciro Indolfi
1Alberto Polimeni, Salvatore De Rosa, and Ciro Indolfi are at the Division of Cardiology, Magna Graecia University, URT Consiglio Nazionale delle Ricerche (CNR), Catanzaro 88100, Italy.
Abstract:
MicroRNAs (miRs) are small non-coding RNAs that regulate gene expression through translational repression or degradation of the target mRNA. Available strategies to improve stent patency lead to the risk of potential stent thrombosis. Modulation of miRs could be a promising means of reducing VSMC proliferation while increasing endothelial regeneration at the same time. Therefore, the goal of this review is to summarize recent experimental evidences on the role played by miRNAs in vascular remodeling, and particularly on VSMC phenotype switch and in endothelial cells, in response to vascular injury.
