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Published on: August 16, 2018
Bioactive barrigenol type triterpenoids from the leaves of Xanthoceras sorbifolia Bunge
Wan Xiao1, Ying Wang, Peng Zhang
1School of Traditional Chinese Materia Medica 49(#), Shenyang Pharmaceutical University, Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Wenhua Road 103, Shenyang 110016, China.
Abstract:
In order to find out new natural barrigenol type triterpenenoids as antitumor agent and reveal the difference on material basis of different parts of Xanthoceras sorbifolia Bunge, the bioassay-directed separation of the saponin fraction from leaves of X. sorbifolia Bunge was carried out to afford 5 new barrigenol type triterpenoids (1-5), together with 2 known ones. The antitumor activities were evaluated and compounds 2 and 7 showed significant cytotoxic activity. Furthermore, the SAR was discussed briefly. On the basis of our research work and related literature, the difference of chemical constituents from different parts of X. sorbifolia was analyzed and concluded. The result can be a useful reference for phytochemistry taxology and safe and rational drug use of X. sorbifolia.
