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Understanding paraneoplastic syndromes in athletes
Robert Cabry1, Smitha Ballyamanda, Michael Kraft
1Drexel Sports Medicine, Drexel University College of Medicine, Philadelphia, PA 19127, USA.
Current Sports Medicine Reports
|January 15, 2013
Summary
Paraneoplastic syndromes arise from cancer secretions affecting hormones and immunity, impacting various body systems. Athletes should monitor symptoms for potential hidden or recurring cancers.
Area of Science:
- Oncology
- Endocrinology
- Immunology
Background:
- Paraneoplastic syndromes result from tumor-secreted substances that disrupt hormonal function and trigger immune responses against normal tissues.
- These disruptions alter metabolic pathways, leading to diverse clinical manifestations affecting multiple organ systems.
- Awareness is crucial, especially for athletes, as these syndromes can indicate underlying malignancies.
Purpose of the Study:
- To review common paraneoplastic syndromes and their association with malignancies.
- To enhance awareness among athletes and healthcare providers regarding the risks of occult or recurrent cancers.
- To provide insights into the mechanisms and clinical impact of paraneoplastic disorders.
Main Methods:
- Literature review focusing on paraneoplastic syndromes and associated cancers.
- Analysis of common malignancies linked to paraneoplastic manifestations.
- Examination of affected organ systems and clinical presentations.
Main Results:
- Commonly associated cancers include small cell lung, breast, gynecologic, and gastrointestinal malignancies.
- Affected systems frequently include neuromuscular, rheumatologic, mucocutaneous, hematologic, renal, and endocrine.
- Diagnosis and treatment of paraneoplastic syndromes are contingent upon managing the primary cancer.
Conclusions:
- Paraneoplastic syndromes are complex disorders linked to underlying cancers.
- Early recognition and understanding are vital for timely diagnosis and management.
- This review aims to inform athletes and caregivers about potential cancer indicators.
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