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High-Throughput Capable Three-Dimensional Tissue Model for Quantification of Electroporation Thresholds
Published on: August 19, 2025
Nonthermal irreversible electroporation: fundamentals, applications, and challenges
Alexander Golberg1, Martin L Yarmush
1Center for Engineering in Medicine, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. agolberg@gmail.com
IEEE Transactions on Bio-Medical Engineering
|January 15, 2013
Summary
Nonthermal irreversible electroporation (NTIRE) uses electric fields for tissue ablation. While its cell death mechanisms are unknown, NTIRE offers precise ablation near blood vessels with preserved tissue architecture and faster recovery.
Area of Science:
- Biomedical Engineering
- Electrophysiology
- Surgical Technology
Background:
- Tissue ablation is crucial for treating various diseases.
- Nonthermal irreversible electroporation (NTIRE) has emerged as a novel ablation technique.
- NTIRE utilizes intensive pulsed electric fields for nonthermal tissue ablation.
Purpose of the Study:
- To provide an overview of Nonthermal Irreversible Electroporation (NTIRE) development.
- To discuss the current state-of-the-art of NTIRE technology.
- To identify challenges and future needs in NTIRE research and application.
Main Methods:
- Review of existing literature on NTIRE.
- Analysis of NTIRE's mechanism of action and outcomes.
- Comparison of NTIRE with traditional ablation techniques.
Main Results:
- NTIRE demonstrates effective tissue ablation near large blood vessels.
- The technique preserves tissue architecture.
- NTIRE offers short procedure durations and reduced postoperative recovery.
Conclusions:
- NTIRE is a promising nonthermal tissue ablation method.
- Further research is needed to elucidate NTIRE's cell death mechanisms.
- NTIRE has significant potential for clinical translation and application.
