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Melanin-concentrating hormone: a structural and conformational study based on synthesis, biological activity,
D W Brown1, M M Campbell, R G Kinsman
1University of Bath, Avon, England.
Biopolymers
|February 15, 1990
Abstract:
A series of Melanin-concentrating hormone (MCH) fragments have been synthesized and their biological activities compared with the parent peptide. The substructural units, 5-14 linear and 5-14 cyclic, have been used as models for MCH-- H-Asp1-Thr-Met-Arg-Cys-Met-Val-Gly-Arg HO-Val17-Glu-Trp-Cys-Pro-Arg-Tyr-Val in 1H-nmr conformational studies. Conformational features predicted by molecular dynamics analyses find support in the nmr experiments.