Related Experiment Video
Updated: May 15, 2026
05:33
Ear Plaster Therapy as a Safe and Effective Treatment for Gestational Vomiting
Published on: August 4, 2023
Sore Throat Treatment during Pregnancy : A Prospective, Controlled, Pilot Study.
M Berkovitch1, R Greenberg, L Gendler
1Clinical Pharmacology and Toxicology Unit, Assaf Harofeh Medical Center, Zerifin, Israel, mberkovitch@asaf.health.gov.il.
Clinical Drug Investigation
|January 15, 2013
Summary
Sore throat lozenges Kalgaron® and Strepsils® appear safe for pregnancy. Studies show no increased risk of birth defects, miscarriage, or low birth weight for mothers using these lozenges during early pregnancy.
Area of Science:
- Obstetrics and Gynecology
- Pharmacovigilance
- Teratology
Background:
- Sore throat is a common ailment during pregnancy.
- The safety of over-the-counter medications, including lozenges, during pregnancy requires careful evaluation.
- Kalgaron® and Strepsils® are commonly used for sore throat relief.
Purpose of the Study:
- To assess the potential association between the use of Kalgaron® or Strepsils® lozenges during the first trimester of pregnancy and adverse pregnancy outcomes.
- To investigate risks of malformations, spontaneous abortions, and decreased birthweight.
Main Methods:
- Prospective, controlled, observational study design.
- Involved 54 pregnant women using Kalgaron® or Strepsils® in the first trimester (study group).
- A control group of 54 pregnant women exposed to non-teratogenic drugs was included for comparison.
Main Results:
- No statistically significant difference in the rate of major malformations between the study group (3.84%) and the control group (3.92%).
- No significant difference in minor malformations between groups (1.92% vs. 0%).
- No significant differences observed in birthweight, live birth rates, or spontaneous abortion rates.
Conclusions:
- Use of Kalgaron® or Strepsils® during pregnancy is not linked to increased risks of malformations, spontaneous abortions, or reduced birthweight.
- Larger studies are recommended to further confirm the safety profile of these lozenges in pregnant populations.
Related Concept Videos
01:30Acute Pharyngitis
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
01:26Tonsillitis II: Management
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
01:23Chronic Pharyngitis
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
01:30Tonsillitis I: Introduction
Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Etiology
Three primary contributing factors have been identified.
01:23Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by anesthetizing...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by anesthetizing...
01:28Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...