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Comparison and evaluation of cardiac biomarkers in patients with intermittent claudication: results from the CAVASIC

Barbara Kollerits1, Gisela Sturm, Claudia Lamina

  • 1Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria.

Clinical Chemistry
|January 15, 2013
PubMed

Insights

Plasma levels of midregional proadrenomedullin (MR-proADM) and C-terminal endothelin-1 precursor fragment (CT-proET-1) are significantly associated with peripheral arterial disease (PAD). These peptides offer additional predictive value beyond NT-proBNP for symptomatic PAD.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Research
  • Vascular Disease

Background:

  • Plasma concentrations of MR-proADM, MR-proANP, and CT-proET-1 are elevated in cardiovascular conditions.
  • Limited data exists on the association and comparative performance of these peptides in peripheral arterial disease (PAD).

Purpose of the Study:

  • To investigate the association of MR-proADM, MR-proANP, and CT-proET-1 plasma concentrations with symptomatic PAD.
  • To compare the performance of these peptides against NT-proBNP in predicting PAD.

Main Methods:

  • The CAVASIC study analyzed plasma concentrations in 238 male patients with intermittent claudication (IC) and 245 matched controls.
  • Associations with symptomatic PAD were assessed, with results compared to NT-proBNP.
  • Statistical models were adjusted for traditional cardiovascular risk factors and C-reactive protein.

Main Results:

  • Increased MR-proADM, MR-proANP, and CT-proET-1 were significantly associated with symptomatic PAD (ORs ranging from 1.32 to 1.80).
  • These associations remained significant after adjusting for traditional risk factors.
  • MR-proADM and CT-proET-1 provided additive predictive information compared to NT-proBNP, even in individuals without prevalent cardiovascular disease.

Conclusions:

  • Elevated MR-proADM, MR-proANP, and CT-proET-1 concentrations are significantly associated with PAD in male patients with IC.
  • MR-proADM and CT-proET-1 demonstrate superior predictive capabilities over NT-proBNP for PAD.
  • These peptides hold promise as valuable biomarkers for PAD risk stratification.
Abstract

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