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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

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Related Experiment Video

Updated: May 15, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Does melanoma begin in a melanocyte stem cell?

James D Hoerter1, Patrick Bradley, Alexandria Casillas

  • 1Department of Biological Sciences, Ferris State University, Big Rapids, MI 49307, USA.

Journal of Skin Cancer
|January 15, 2013
PubMed
Summary
This summary is machine-generated.

Zebrafish models reveal how melanocyte stem cells (MSCs) respond to UV radiation, offering insights into melanoma development. This research explores UV-induced damage to MSCs and their role in melanoma formation.

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Last Updated: May 15, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma
12:16

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

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Feeder-free Derivation of Melanocytes from Human Pluripotent Stem Cells
12:21

Feeder-free Derivation of Melanocytes from Human Pluripotent Stem Cells

Published on: March 3, 2016

Area of Science:

  • * Developmental biology
  • * Cancer research
  • * Dermatology

Background:

  • * The cellular origins of melanoma and the role of melanocyte stem cells (MSCs) remain incompletely understood.
  • * Melanocyte precursors' susceptibility to environmental factors like solar radiation is a key question in melanoma research.

Purpose of the Study:

  • * To investigate the role of zebrafish melanocyte stem cells (MSCs) in melanoma development.
  • * To explore how UVA and UVB radiation affect MSCs and potentially contribute to melanoma formation.
  • * To review MSCs in zebrafish and methods for manipulating these populations for experimental study.

Main Methods:

  • * Utilizing the zebrafish model for its regenerative capabilities to study MSC regulation and recruitment.
  • * Investigating the effects of UVA and UVB radiation on MSC proliferation, survival, repair, and differentiation.
  • * Reviewing existing literature on zebrafish MSCs and experimental techniques for manipulating MSC populations.

Main Results:

  • * Zebrafish models allow for the study of MSC behavior in response to environmental stimuli and injury.
  • * UV radiation's impact on MSCs can be assessed to understand their contribution to melanoma development.
  • * Experimental techniques exist to manipulate MSC populations for targeted research.

Conclusions:

  • * Zebrafish provide a powerful model for studying the cellular origins of melanoma, particularly the role of MSCs.
  • * Understanding UV-induced damage to MSCs is crucial for elucidating melanoma pathogenesis.
  • * Further research using zebrafish can address critical questions about melanoma stem cells and tumor formation.