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Related Experiment Video

Updated: May 15, 2026

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

What really causes necrotising enterocolitis?

Thomas Peter Fox¹, Charles Godavitarne

¹General Medicine, King's College Hospital, London SE5 9RS, UK.

ISRN Gastroenterology

|January 15, 2013

Summary

This summary is machine-generated.

Necrotising enterocolitis (NEC) is a severe neonatal gastrointestinal disorder with unknown causes. This review examines numerous risk factors, highlighting NEC

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In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

Published on: June 8, 2022

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Last Updated: May 15, 2026

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

Published on: June 8, 2022

Area of Science:

Neonatal Medicine
Gastroenterology
Pediatric Surgery

Background:

Necrotising enterocolitis (NEC) is a critical gastrointestinal emergency in neonates.
It presents high mortality and morbidity, posing a significant challenge in neonatal care.
The exact cause of NEC is undetermined, with numerous proposed risk factors.

Purpose of the Study:

To conduct a comprehensive literature review on NEC risk factors.
To consolidate information on both well-documented and less-recognized NEC risk factors.

Main Methods:

Searched Medline, Embase, and Science Direct databases.
Used search terms like "necrotising enterocolitis + risk factor".
Prioritized recent publications and relevance.

Main Results:

Identified approximately 20 proposed risk factors for NEC.
Highlighted the complexity and multifactorial nature of NEC aetiology.

Conclusions:

NEC is a complex condition with likely multiple contributing factors.
Further research is required to determine the specific impact of each risk factor on NEC development.