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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

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Updated: May 15, 2026

Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs
09:47

Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs

Published on: June 17, 2016

Mesenchymal stem cells and the lung.

Kenneth Sinclair1, Stephanie T Yerkovich, Daniel C Chambers

  • 1Queensland Lung Transplant Service, The Prince Charles Hospital, Brisbane, Queensland, Australia. kenneth.sinclair@uqconnect.edu.au

Respirology (Carlton, Vic.)
|January 16, 2013
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells (MSC) are adult progenitor cells found in bone marrow and lungs. This review highlights their role in lung repair and the potential of MSC-based therapies.

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Area of Science:

  • Regenerative Medicine
  • Cell Biology
  • Pulmonology

Background:

  • Mesenchymal stem cells (MSCs) are adult progenitor cells initially found in bone marrow.
  • MSCs have since been identified in various organs, including the lungs.
  • Their exact function in organ physiology is still under investigation.

Purpose of the Study:

  • To review current knowledge of Mesenchymal stem cell (MSC) biology.
  • To focus on MSCs within the context of lung biology.
  • To explore the therapeutic applications of MSC-based cell therapy.

Main Methods:

  • Literature review of Mesenchymal stem cell (MSC) research.
  • Analysis of studies focusing on lung MSCs.
  • Evaluation of Mesenchymal stem cell (MSC)-based therapeutic strategies.

Main Results:

  • Mesenchymal stem cells (MSCs) are crucial components of the progenitor cell niche.
  • Evidence suggests MSCs play a role in maintaining lung homeostasis.
  • MSCs are implicated in orchestrating repair mechanisms following lung injury.

Conclusions:

  • Mesenchymal stem cells (MSCs) are vital for lung repair and homeostasis.
  • Further research into MSC biology is warranted.
  • MSC-based therapies show promise for treating lung diseases.