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Updated: May 15, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

Morbidity and outcome of severe respiratory syncytial virus infection

Amani A El Kholy1, Nadia A Mostafa, Seham A El-Sherbini

  • 1Department of Clinical and Chemical Pathology, Cairo University, Cairo, Egypt.

Pediatrics International : Official Journal of the Japan Pediatric Society
|January 16, 2013
PubMed

Insights

Respiratory syncytial virus (RSV) is a major cause of severe acute respiratory infection in children. Identifying risk factors like cyanosis and lung consolidation can help predict severe disease and guide early intensive care unit admission.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Respiratory syncytial virus (RSV) is a primary cause of severe acute respiratory infection (SARI) in infants and young children.
  • Hospitalized children with SARI due to RSV face risks of intensive care unit (ICU) admission, prolonged hospitalization, and mortality.

Purpose of the Study:

  • To identify independent risk factors associated with ICU admission.
  • To determine predictors for prolonged length of stay (PLOS) in hospitalized children with RSV-SARI.
  • To identify risk factors for mortality in pediatric patients with RSV-SARI.

Main Methods:

  • Prospective cohort study of children hospitalized with SARI and confirmed RSV infection.
  • Data collected from February 2010 to May 2011.
  • Statistical analysis to identify independent risk factors for ICU admission, PLOS, and mortality.

Main Results:

  • Out of 240 patients, 10% required ICU admission, 24.3% had PLOS >9 days, and 5% died.
  • Cyanosis and lung consolidation were independent predictors of ICU admission.
  • ICU admission and lung consolidation predicted PLOS.
  • Congenital heart disease, thrombocytopenia, and mechanical ventilation were independent risk factors for mortality.

Conclusions:

  • Early identification of risk factors for complicated RSV disease is crucial.
  • Prompt interventions and timely ICU admission for high-risk children can improve outcomes.
Abstract

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