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Updated: May 15, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Enantioselective liquid-liquid extractions of underivatized general amino acids with a chiral ketone extractant
Haofei Huang1, Raju Nandhakumar, Misun Choi
1Bio-Chiral Lab, Department of Chemistry & Nano Science, Ewha Womans University, Seoul 120-750, Korea.
Abstract:
The chiral ketone (S)-3 shows high kinetic enantioselectivities toward the L form for general underivatized amino acids with hydrophobic side chains and a high thermodynamic enantioselectivity toward the D form for cysteine with its -SH polar side chain when used as an extractant in enantioselective liquid-liquid extractions in the presence of Aliquat 336. Consecutive extractions by imine formation and hydrolysis increase the enantiopurity of the amino acid, as both of these reactions are L-form-selective.
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