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Related Experiment Video

Updated: May 15, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Generalized perforating granuloma annulare: case report.

Joana Alexandra Devesa Parente1, José Alberto Machado Dores, João Manuel Pires Aranha

  • 1Department of Dermatology, Santarém District Hospital EPE, Portugal. parentejoana81@hotmail.com

Acta Dermatovenerologica Croatica : ADC
|January 16, 2013
PubMed
Summary

Perforating granuloma annulare, a rare skin condition, was diagnosed in a patient who later developed acquired immunodeficiency syndrome (AIDS). This case highlights a potential link between atypical granuloma annulare variants and HIV infection.

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Area of Science:

  • Dermatology
  • Immunology
  • Infectious Diseases

Background:

  • Granuloma annulare is a benign inflammatory skin condition.
  • Atypical variants, such as the perforating type, are less common.
  • Human immunodeficiency virus (HIV) infection can alter immune responses and disease presentations.

Observation:

  • A 26-year-old male presented with an 8-month history of asymptomatic, symmetrical erythematous papulonodular lesions on the face, trunk, and limbs.
  • Histopathology revealed features consistent with perforating granuloma annulare, including palisading granulomas, necrobiotic collagen, mucin deposition, and transepidermal elimination of collagen.

Findings:

  • The patient was subsequently diagnosed with acquired immunodeficiency syndrome (AIDS) following sepsis secondary to gastroenteritis.

Related Experiment Videos

Last Updated: May 15, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

  • Positive serologic tests for HIV antibodies confirmed the AIDS diagnosis.
  • This case suggests a potential association between perforating granuloma annulare and advanced HIV infection.

    • Implications:

    • Atypical granuloma annulare variants, particularly perforating types, may serve as a cutaneous manifestation of underlying acquired immunodeficiency syndrome (AIDS).
    • HIV infection can significantly modify the clinical presentation and course of granuloma annulare due to immune dysregulation.
    • Early recognition of such dermatological signs in at-risk individuals may prompt investigation for opportunistic infections and immunodeficiency.