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Published on: October 23, 2018
mTOR in aging, metabolism, and cancer
Marion Cornu1, Verena Albert, Michael N Hall
1Biozentrum, University of Basel, CH-4056 Basel, Switzerland.
Abstract:
The target of rapamycin (TOR) is a highly conserved serine/threonine kinase that is part of two structurally and functionally distinct complexes, TORC1 and TORC2. In multicellular organisms, TOR regulates cell growth and metabolism in response to nutrients, growth factors and cellular energy. Deregulation of TOR signaling alters whole body metabolism and causes age-related disease. This review describes the most recent advances in TOR signaling with a particular focus on mammalian TOR (mTOR) in metabolic tissues vis-a-vis aging, obesity, type 2 diabetes, and cancer.
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