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Related Concept Videos

Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Irritable Bowel Syndrome I: Introduction

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Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...
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Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors

Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI)  tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining. Bicarbonate,...
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Pathophysiology of Peptic Ulcer Disease: Injurious Factors

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Related Experiment Video

Updated: May 15, 2026

The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management
06:40

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Published on: June 29, 2019

Changes in gastrointestinal tract function and structure in functional dyspepsia.

Hanne Vanheel1, Ricard Farré

  • 1Translational Research Center for Gastrointestinal Disorders, KU Leuven, Herestraat 49, Box 701, 3000 Leuven, Belgium.

Nature Reviews. Gastroenterology & Hepatology
|January 16, 2013
PubMed
Summary
This summary is machine-generated.

Functional dyspepsia, a common gut disorder, involves stomach issues like poor accommodation and delayed emptying, alongside duodenal sensitivity and inflammation. Understanding these varied mechanisms is key to managing this heterogeneous condition.

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Gastrointestinal Motility Monitor (GIMM)
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Gastrointestinal Motility Monitor (GIMM)
08:15

Gastrointestinal Motility Monitor (GIMM)

Published on: December 1, 2010

Area of Science:

  • Gastroenterology
  • Digestive Health
  • Functional Gastrointestinal Disorders

Background:

  • Functional dyspepsia (FD) is a prevalent gastrointestinal disorder characterized by upper abdominal symptoms.
  • FD is considered a heterogeneous condition with diverse underlying pathophysiological mechanisms.
  • Varied symptom patterns in FD suggest distinct functional and structural abnormalities.

Purpose of the Study:

  • To provide an integrated overview of the pathophysiological mechanisms in functional dyspepsia.
  • To summarize known abnormalities in the stomach and duodenum associated with FD.
  • To highlight the heterogeneity of FD based on underlying functional changes.

Main Methods:

  • Review of existing literature on functional dyspepsia.
  • Synthesis of described changes in gastrointestinal tract function and structure.
  • Analysis of abnormalities in stomach and duodenal function.

Main Results:

  • Common findings include impaired gastric accommodation and delayed gastric emptying.
  • Gastric hypersensitivity and increased duodenal sensitivity to acid/lipids are frequently observed.
  • Low-grade inflammation in the duodenum is a recognized abnormality in some FD patients.

Conclusions:

  • Functional dyspepsia encompasses a range of gastrointestinal dysfunctions.
  • Abnormalities in both the stomach and duodenum contribute to FD.
  • An integrated understanding of these mechanisms is crucial for effective management of FD.