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Grover's Disease after Heart Transplantation: A Case Report

Giovanbattista Ippoliti1, Marco Paulli, Marco Lucioni

  • 1Division of Cardiac Surgery, IRCCS San Matteo Hospital Foundation, University of Pavia School of Medicine, 27100 Pavia, Italy ; U.O. Medicina Interna, Policlinico di Monza, Monza, Italy.

Case Reports in Transplantation
|January 16, 2013
PubMed

Insights

Grover's disease, a transient skin condition, can occur after heart transplantation. This case report details the first known instance of this association, highlighting a potential link between cardiac transplants and this dermatosis.

Area of Science:

  • Dermatology
  • Transplant Surgery

Background:

  • Grover's disease (transient acantholytic dermatosis) presents as a papular eruption, typically on the chest and abdomen.
  • It is histologically defined by acantholysis and linked to various conditions like malignancies, renal failure, HIV, and transplants.
  • Disease course can be complicated by spontaneous remission and fluctuations.

Purpose of the Study:

  • To report the first documented case of Grover's disease following heart transplantation.
  • To investigate the potential association between cardiac transplantation and the onset of Grover's disease.

Main Methods:

  • Case report of a patient who developed Grover's disease post-heart transplant.
  • Clinical and histological evaluation of the dermatosis.

Main Results:

  • Sudden onset of Grover's disease observed in a patient after heart transplantation.
  • This represents the first reported case of this specific post-transplant complication.

Conclusions:

  • Heart transplantation may be a potential trigger for Grover's disease.
  • Further research is warranted to understand the relationship between cardiac transplants and transient acantholytic dermatosis.

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