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Intraoperative electron beam radiotherapy for primary treatment of stage IIB cervical cancer: a retrospective study
1Department of Radiation Oncology, First Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an, China. liuzmail@163.com
Objective:
A retrospective study to evaluate intraoperative electron beam radiotherapy (IOERT) as a primary treatment modality for stage IIB cervical squamous cell carcinoma.
Methods:
Patients underwent treatment with IOERT (n = 78) or radical radiotherapy (RT; n = 89). Patients in the IOERT group received 20 Gy external beam radiotherapy (EBRT) in 10 fractions, intracavitary brachytherapy (7-14 Gy, in patients with tumours ≥ 4 cm in diameter) and simple hysterectomy/selective lymphadenectomy with 18 - 20 Gy IOERT. Patients in the RT group received 50 Gy EBRT in 25 fractions followed by intracavitary brachytherapy (35-40 Gy).
Results:
Median duration of follow-up was 92 months. IOERT resulted in significantly better 5- and 10-year overall survival, disease-free survival and local control rates, as well as fewer rectal and bladder complications, compared with RT.
Conclusion:
IOERT is an effective primary treatment for stage IIB cervical squamous cell carcinoma.
