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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

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Related Experiment Video

Updated: May 15, 2026

Isolating Mesangiogenic Progenitor Cells (MPCs) from Human Bone Marrow
09:53

Isolating Mesangiogenic Progenitor Cells (MPCs) from Human Bone Marrow

Published on: July 15, 2016

Mesenchymal stromal cells: misconceptions and evolving concepts.

Donald G Phinney1, Luc Sensebé

  • 1Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA. dphinney@scripps.edu

Cytotherapy
|January 17, 2013
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells (MSCs) have evolved in definition over 50 years. This review clarifies persistent misconceptions about MSCs to advance their therapeutic applications.

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Last Updated: May 15, 2026

Isolating Mesangiogenic Progenitor Cells (MPCs) from Human Bone Marrow
09:53

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Published on: July 15, 2016

Production and Administration of Therapeutic Mesenchymal Stem/Stromal Cell (MSC) Spheroids Primed in 3-D Cultures Under Xeno-free Conditions
11:05

Production and Administration of Therapeutic Mesenchymal Stem/Stromal Cell (MSC) Spheroids Primed in 3-D Cultures Under Xeno-free Conditions

Published on: March 18, 2017

Area of Science:

  • Cell Biology
  • Stem Cell Research
  • Regenerative Medicine

Background:

  • Mesenchymal stem cells (MSCs), initially termed colony-forming unit fibroblasts, have undergone significant reclassifications, including marrow stromal cells and mesenchymal stem cells.
  • Over nearly five decades, the understanding of MSCs' complex biology and therapeutic potential has evolved substantially.
  • Despite advances, persistent misconceptions about MSCs' nature and function may hinder clinical translation.

Purpose of the Study:

  • To identify and address prevalent misconceptions surrounding Mesenchymal Stem Cells (MSCs).
  • To rectify inaccuracies in the field based on current scientific data.
  • To facilitate the advancement of MSC-based therapies in clinical settings.

Main Methods:

  • Literature review and data analysis.
  • Identification of six prevalent misconceptions regarding MSCs.
  • Rectification of misconceptions based on current scientific evidence.

Main Results:

  • Six key misconceptions about Mesenchymal Stem Cells (MSCs) were identified and addressed.
  • The study provides data-driven corrections to long-standing inaccuracies in MSC biology and function.
  • Clarification aims to prevent the impediment of MSC-based therapy development.

Conclusions:

  • Addressing misconceptions is crucial for the accurate understanding and application of MSCs.
  • Correcting prevalent inaccuracies will accelerate the clinical translation of MSC therapies.
  • This work provides a foundation for future research and therapeutic development involving MSCs.