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Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Mucosal Barrier of the Stomach01:25

Mucosal Barrier of the Stomach

The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
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Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Vaccines01:21

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Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Vaccinations01:51

Vaccinations

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Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria
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Published on: December 8, 2023

Mucosal Lactobacillus vectored vaccines.

Qinghua Yu1, Liqi Zhu, Haihong Kang

  • 1Nanjing Agricultural University; Nanjing, Jiangsu P.R. China.

Human Vaccines & Immunotherapeutics
|January 17, 2013
PubMed
Summary

Lactobacillus-based vaccines offer a promising strategy to combat mucosal infections. Oral or intranasal administration can induce robust immune responses, enhancing protection against pathogens entering through mucosal pathways.

Keywords:
Lactobacillusmucosalvaccine delivery

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Area of Science:

  • Immunology
  • Microbiology
  • Vaccinology

Background:

  • Traditional vaccines often fail to elicit sufficient mucosal immunity against pathogens entering via oral, intranasal, or vaginal routes.
  • Lactobacillus species are safe, immunomodulatory commensals in the gastrointestinal tract, closely associated with the intestinal epithelium.

Purpose of the Study:

  • To evaluate Lactobacillus species as live vaccine vehicles for delivering immunogens to mucosal surfaces.
  • To explore the potential of Lactobacillus-based vaccines for controlling mucosal infections.

Main Methods:

  • Utilizing Lactobacillus species as live vehicles for immunogen delivery.
  • Administering Lactobacillus-based vaccines orally or intranasally.

Main Results:

  • Lactobacillus-based vaccines demonstrate potential for inducing significant immune responses.
  • Effective induction of both humoral and cellular immunity at systemic and mucosal sites.

Conclusions:

  • Lactobacillus-based vaccines represent a promising approach for developing effective mucosal vaccines.
  • Oral and intranasal administration of these vaccines can enhance protection against mucosal pathogens.