Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rheumatic Heart Disease I: Introduction

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Rehabilitation Underutilization: Using a Model of Rheumatoid Arthritis to Illustrate Unmet Needs.

Archives of rehabilitation research and clinical translation·2026

Same author

Clinical-scale 10-day TCR-T cell manufacturing using IL-2/7/15 and TGF-β promotes early memory and tissue-resident-like phenotypes and robust antitumor activity <i>in vitro</i>.

Frontiers in immunology·2026

Same author

Bidirectional associations between daily sleep and pain severity in adults with rheumatoid arthritis: A daily diary and actigraphy study.

The journal of pain·2026

Same author

Neighborhood Socioeconomic Status and Short-Term Functional Outcomes in Systemic Lupus Erythematosus.

Arthritis care & research·2026

Same author

Demographic and clinical characteristics of patients with systemic lupus erythematosus across five registries: the LupusNet federated data network.

Lupus science & medicine·2026

Same author

Loss of Lean Mass in Rheumatoid Arthritis Is Associated With Loss of Total and Visceral Fat.

Journal of cachexia, sarcopenia and muscle·2026

Search research articles

Related Experiment Video

Updated: May 15, 2026

Evaluation of Changes in Hydration and Body Cell Mass with Bioelectrical Impedance Analysis after Exercise Program for Rheumatoid Arthritis Patients

Evaluation of Changes in Hydration and Body Cell Mass with Bioelectrical Impedance Analysis after Exercise Program for Rheumatoid Arthritis Patients

Published on: July 14, 2023

The relationship between cognitive function and physical function in rheumatoid arthritis.

So Young Shin¹, Laura Julian, Patricia Katz

¹College of Nursing, Keimyung University, Daegu, South Korea. fantasy45@gmail.com

The Journal of Rheumatology

|January 17, 2013

Summary

Cognitive impairment is linked to increased functional limitations in rheumatoid arthritis (RA) patients. This suggests that cognitive decline may contribute to poorer physical function in individuals with RA.

More Related Videos

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Related Experiment Videos

Last Updated: May 15, 2026

Evaluation of Changes in Hydration and Body Cell Mass with Bioelectrical Impedance Analysis after Exercise Program for Rheumatoid Arthritis Patients

Evaluation of Changes in Hydration and Body Cell Mass with Bioelectrical Impedance Analysis after Exercise Program for Rheumatoid Arthritis Patients

Published on: July 14, 2023

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Area of Science:

Rheumatology
Neuropsychology
Gerontology

Background:

Rheumatoid arthritis (RA) is a chronic autoimmune disease.
Cognitive impairment can affect individuals with RA.
The relationship between cognitive function and physical limitations in RA is not fully understood.

Purpose of the Study:

To investigate the association between cognitive impairment and functional limitations and disability in patients with rheumatoid arthritis.

Main Methods:

A longitudinal cohort study of RA patients was conducted.
Cognitive function was assessed using 12 standardized neuropsychological tests.
Functional limitations were measured using the Short Physical Performance Battery (SPPB) and Health Assessment Questionnaire (HAQ).
Disability was assessed using the Valued Life Activities (VLA) scale.
Multiple regression analyses were performed, controlling for relevant covariates.

Main Results:

The study included 122 RA patients (mean age 58.4 years, 62% female, 80% white).
Total cognitive impairment score was significantly associated with greater functional limitations (SPPB and HAQ).
Cognitive impairment was not significantly associated with self-reported disability (VLA).

Conclusions:

Cognitive impairment is significantly associated with increased functional limitations in patients with rheumatoid arthritis.
Cognitive impairment may play a role in the reduced functional status observed in RA patients.