Related Experiment Video
Updated: May 15, 2026

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis
Published on: December 1, 2023
Presumptive progressive multifocal leukoencephalopathy in multiple sclerosis after natalizumab therapy
Philipp Eisele1, Kristina Szabo, Eva Hornberger
1Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Germany.
Background And Purpose:
To describe a patient with relapsing remitting MS who was treated with natalizumab for 36 months. First symptoms of presumptive progressive multifocal leukoencephalopathy (PML) appeared 14 weeks after her last natalizumab infusion.
Methods:
Neurological examination, MRI and CSF analysis were performed.
Results:
The lack of anti-inflammatory treatment response, clinical course, and serial MRI examinations showed lesion development typical for PML on diffusion-weighted and FLAIR MRI. CSF analysis for JC virus was tested negative twice.
Conclusions:
This case represents a presumptive PML after discontinuation of natalizumab treatment-similar to the definition established for PML in HIV patients.
Related Concept Videos
Multiple Sclerosis l: Introduction
Encephalitis l: Introduction
Encephalitis ll: Pathophysiology
