Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Severe hidradenitis suppurativa exacerbation in temporal association with PD-1 blockade in cutaneous squamous cell carcinoma.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026

Same author

Features of Skin of Color.

Deutsches Arzteblatt international·2026

Same author

A STAT1/ETC/GBP1 axis represents a potential therapeutic target for noncommunicable granulomatous skin disease.

Science advances·2026

Same author

Familial hidradenitis suppurativa is associated with an increased prevalence of metabolic and cardiovascular comorbidity.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026

Same author

Directional dark field for nanoscale full-field transmission X-ray microscopy.

Light, science & applications·2026

Same author

Extending the Field of View in Modulation-Based X-Ray Phase Microtomography.

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society·2026

Search research articles

Related Experiment Video

Updated: May 15, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

Animal model for cutaneous leishmaniasis.

Michael R Fischer¹, Dominik John, Kordula Kautz-Neu

¹Department of Dermatology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.

Methods in Molecular Biology (Clifton, N.J.)

|January 18, 2013

Summary

This summary is machine-generated.

This study details a new mouse model for studying cutaneous leishmaniasis, enhancing our understanding of immune responses to Leishmania major. The model closely mimics natural sand fly transmission for more accurate research on leishmaniasis immunity.

More Related Videos

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

Published on: February 20, 2020

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

Published on: July 27, 2010

Related Experiment Videos

Last Updated: May 15, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

Published on: February 20, 2020

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

Published on: July 27, 2010

Area of Science:

Immunology
Infectious Diseases
Parasitology

Background:

T helper (Th) cells type 1 and type 2 were identified over 20 years ago in murine cutaneous leishmaniasis.
Immunity against Leishmania major requires T cell populations beyond Th1/Th2 and B cell-mediated immunity.
Genetic factors and skin-immune system elements influencing anti-pathogen immunity have been identified in inbred mouse strains.

Purpose of the Study:

To describe a refined model for experimental leishmaniasis in mice.
To better mimic natural parasite transmission routes and infectious doses.

Main Methods:

Utilized infectious-stage Leishmania parasites found in sand fly saliva.
Administered parasites via intradermal inoculation.
Infected mice with a low dose (1,000 parasites) to simulate natural transmission.

Main Results:

The described model provides a more accurate representation of natural Leishmania transmission.
Facilitates the study of T cell and B cell immunity in murine leishmaniasis.
Allows for investigation into genetic influences on anti-parasitic immunity.

Conclusions:

The developed murine model offers a valuable tool for leishmaniasis research.
Enhances understanding of the complex immune mechanisms against Leishmania major.
Supports further investigation into host-pathogen interactions and immune evasion strategies.