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Quantitative Determination of Ciprofibrate in Tablets by Derivative UV Spectroscopy and RP-HPLC Method.

P S Jain¹, H N Jivani, R N Khatal

¹Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur-425 405, India.

Indian Journal of Pharmaceutical Sciences

|January 18, 2013

Summary

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A new derivative UV spectrophotometric method accurately determines ciprofibrate in tablets. This method offers a precise and reliable alternative to traditional chromatographic techniques for pharmaceutical analysis.

Area of Science:

Analytical Chemistry
Pharmaceutical Analysis

Background:

Accurate quantification of active pharmaceutical ingredients (APIs) like ciprofibrate is crucial for drug quality control.
Existing analytical methods may require optimization for improved efficiency and accuracy in pharmaceutical formulations.

Purpose of the Study:

To develop and validate a derivative UV spectrophotometric method for ciprofibrate determination in tablets.
To compare the performance of the developed method against established reference techniques.

Main Methods:

Development of a first-order derivative UV spectrophotometric method.
Validation of accuracy (recovery: 100.57±0.97) and precision (coefficient of variation: 1.44).
Comparison with zero-order UV spectrophotometry and reversed-phase high-performance liquid chromatography (RP-HPLC) using a C(8) column and methanol:water mobile phase at 232 nm.

Keywords:

Ciprofibrate content determination derivative UV spectrophotometry reversed phase high-performance liquid chromatographic

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Main Results:

The derivative UV spectrophotometric method demonstrated high accuracy and precision.
Statistical analysis (ANOVA test, P = 0.0226, F = 4.935) confirmed the comparability of results with reference methods.
RP-HPLC method utilized a C(8) column with a methanol:water mobile phase (90:10, v/v, pH 3.7) and detection at 232 nm for calibration solutions from 2 to 12 μg/ml.

Conclusions:

The developed derivative UV spectrophotometric method is a valid and reliable technique for ciprofibrate quantification in tablet formulations.
This spectrophotometric approach offers a comparable alternative to chromatographic methods, potentially simplifying pharmaceutical quality control procedures.