Prolonged QT dispersion in inflammatory bowel disease.
Elif Yorulmaz1, Aslıhan Sezgin, Hatice Yorulmaz
1Department of Gastroenterology, Goztepe Training and Research Hospital, 34470 Istanbul, Turkey.
World Journal of Gastroenterology
|January 18, 2013
Summary
Inflammatory bowel disease (IBD) patients exhibit prolonged QT dispersion, a potential risk factor for arrhythmias. Routine monitoring should include insulin resistance assessment and electrocardiograms for early detection.
Area of Science:
- Cardiology
- Gastroenterology
- Metabolic Syndrome
Background:
- Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), is associated with various extraintestinal manifestations.
- Cardiac involvement in IBD is increasingly recognized, necessitating investigation into potential risk factors for arrhythmias.
Purpose of the Study:
- To determine the prevalence of prolonged corrected QT dispersion (QTcd) in patients with IBD.
- To identify factors associated with prolonged QTcd in IBD patients, particularly insulin resistance (IR).
Main Methods:
- Electrocardiography was used to measure QTcd in 63 UC patients, 41 CD patients, and 47 healthy controls.
- Homeostasis model assessment (HOMA) was employed to assess insulin resistance (IR), with HOMA > 2.5 indicating high IR.
- Statistical analyses were performed to compare QTcd, insulin, HOMA, blood pressure, and age between IBD subgroups and controls.
Main Results:
- Prolonged QTcd was observed in 12.2% of UC patients and 14.5% of CD patients, significantly higher than in controls (P < 0.05).
- IBD patients with prolonged QTcd showed significantly higher insulin and HOMA values, indicating increased insulin resistance (P < 0.05).
- Increased systolic arterial pressure and older age were significantly associated with prolonged QTcd in UC patients (P < 0.01 and P < 0.05, respectively).
Conclusions:
- Patients with IBD demonstrate a higher frequency of prolonged QTcd compared to healthy individuals.
- Insulin resistance, assessed by HOMA and insulin levels, is a significant factor associated with prolonged QTcd in IBD.
- Routine cardiovascular monitoring, including ECG and IR assessment, is recommended for IBD patients to mitigate arrhythmia risk.
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