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A case of diffuse endocapillary proliferative glomerulonephritis associated with polymyalgia rheumatica
Eri Takeshima1, Yoshiyuki Morishita, Manabu Ogura
1Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke-shi, Japan.
Case Reports in Nephrology and Urology
|January 18, 2013
Summary
Polymyalgia rheumatica (PMR) can present with rare kidney complications like glomerulonephritis. Early diagnosis and low-dose steroid treatment effectively managed these symptoms, improving muscle pain and kidney function.
Area of Science:
- Nephrology
- Rheumatology
- Internal Medicine
Background:
- Polymyalgia rheumatica (PMR) is an inflammatory condition typically affecting individuals over 50.
- Renal involvement in PMR is uncommon but can manifest as glomerulonephritis.
Observation:
- A 70-year-old male presented with characteristic PMR symptoms: neck, shoulder, and pelvic girdle muscle pain.
- He subsequently developed proteinuria and hematuria, with elevated acute phase reactants.
- Renal biopsy revealed diffuse endocapillary proliferative glomerulonephritis.
Findings:
- The patient's clinical presentation met diagnostic criteria for PMR.
- No evidence of autoimmune diseases, malignancy, or infections was found.
- A diagnosis of diffuse endocapillary proliferative glomerulonephritis associated with PMR was established.
Implications:
- Low-dose prednisolone (10 mg/day) treatment led to symptom resolution, decreased inflammatory markers, and improved renal function.
- This case highlights the importance of considering renal complications in PMR patients.
- Early recognition and management of glomerulonephritis in PMR can prevent significant kidney damage.
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