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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Sympathetic Pathways: Sympathetic Chain Ganglia

The sympathetic chain ganglia, also known as the sympathetic trunk ganglia or paravertebral ganglia, are a series of ganglia located bilaterally on either side of the spinal column. These ganglia serve as relay stations for the sympathetic nervous system. Preganglionic neurons originating in the spinal cord project their axons to the sympathetic chain ganglia. Within the ganglia, these preganglionic fibers synapse with postganglionic neurons.The postganglionic neurons of the sympathetic trunk...

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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Benign cutaneous neural tumors.

José Luis Rodríguez-Peralto1, Erica Riveiro-Falkenbach, Rosario Carrillo

  • 1Department of Pathology, Hospital Universitario 12 de Octubre, Instituto de Investigación i+12, Universidad Complutense, Madrid, Spain. jrodriguezp.hdoc@salud.madrid.org

Seminars in Diagnostic Pathology
|January 19, 2013
PubMed
Summary
This summary is machine-generated.

Benign cutaneous neural neoplasms are common skin tumors. This review details their characteristic features and uncommon variants, aiding distinction from other spindle-cell tumors.

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Area of Science:

  • Dermatopathology
  • Surgical Pathology
  • Oncology

Background:

  • Benign cutaneous neural neoplasms are frequent mesenchymal tumors of the skin.
  • Peripheral nerve sheath tumors exhibit cellular diversity due to the complex cell composition of peripheral nerves.
  • While often easily diagnosed via characteristic features and immunohistochemistry, rare variants pose diagnostic challenges.

Purpose of the Study:

  • To present the clinical and histopathological features of common benign cutaneous neural tumors.
  • To highlight uncommon variants requiring differentiation from other spindle-cell neoplasms.
  • To provide a comprehensive overview for accurate diagnosis.

Main Methods:

  • Review of clinical presentations of benign cutaneous neural tumors.
  • Histopathological analysis of tumor constituents and their arrangement.
  • Immunohistochemical profiling for specific protein expression.
  • Comparison with differential diagnoses, including melanoma and other spindle-cell tumors.

Main Results:

  • Benign neural tumors display varied proportions and arrangements of nerve constituents.
  • Characteristic features aid diagnosis, but infrequent variants necessitate careful evaluation.
  • Immunohistochemistry is crucial for identifying specific cell types and confirming neural origin.

Conclusions:

  • Accurate diagnosis of benign cutaneous neural neoplasms relies on recognizing characteristic histopathological features.
  • Awareness of uncommon variants and their distinction from malignant tumors is essential.
  • Comprehensive understanding of these tumors improves patient management and diagnostic accuracy.