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Meta-analyses of four eosinophil related gene variants in coronary heart disease

Jiangfang Lian1, Yi Huang, R Stephanie Huang

  • 1Ningbo Medical Center, Lihuili Hospital, Ningbo University, Ningbo, 315041, Zhejiang, China.

Journal of Thrombosis and Thrombolysis
|January 19, 2013
PubMed

Insights

Genetic variants in eosinophil-related genes were studied for their link to coronary heart disease (CHD). The SH2B3 gene variant rs3184504 showed a significant association with CHD risk in European and South Asian populations.

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology
  • Immunology

Background:

  • Eosinophils play a role in inflammation and immune responses.
  • Genetic variations can influence susceptibility to complex diseases like coronary heart disease (CHD).
  • Previous research suggests potential links between eosinophil-related genes and cardiovascular health.

Purpose of the Study:

  • To investigate the association between four specific eosinophil-related gene variants (rs12619285, rs1420101, rs3184504, and rs4143832) and the risk of developing coronary heart disease (CHD).
  • To evaluate the contribution of these genetic variants to CHD risk across different ethnic populations.

Main Methods:

  • Conducted systematic literature searches across multiple databases (MEDLINE, EMBASE, Web of Science, CNKI, Wanfang).
  • Performed meta-analyses of existing studies and a new case-control study (162 CHD cases, 119 controls).
  • Focused meta-analysis on rs3184504 in the SH2B3 gene using 19 study stages and 94,555 participants.

Main Results:

  • A significant association was found between the rs3184504 variant in the SH2B3 gene and increased CHD risk in European and South Asian populations (OR = 1.13, 95% CI = 1.10-1.16, p < 0.0001).
  • No significant association was observed for rs12619285, rs1420101, and rs4143832 with CHD risk when combining case-control data with previous studies.
  • The four genetic variants did not show a significant contribution to CHD risk in the Han Chinese population.

Conclusions:

  • The rs3184504 variant of the SH2B3 gene is significantly associated with coronary heart disease risk in European and South Asian populations.
  • No significant association was found for the studied eosinophil-related gene variants with CHD risk in the Han Chinese population.
  • These findings highlight population-specific genetic influences on coronary heart disease susceptibility.

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