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Updated: May 15, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
Published on: November 16, 2011
[Hyperinsulinemic hypoglycemia of the infancy: analysis of clinical data from a Brazilian sample]
Raphael Del Roio Liberatore Junior1, Alcinda Aranha Negri, Carlos Eduardo Martinelli Junior
1Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brasil. liberat@famerp.br
Objective:
To review the presentation of hyperinsulinemic hypoglycemia of the infancy (HHI), its treatment and histology in Brazilian pediatric endocrinology sections.
Materials And Method:
The protocol analyzed data of birth, laboratory results, treatment, surgery, and pancreas histology.
Results:
Twenty-five cases of HHI from six centers were analyzed: 15 male, 3/25 born by vaginal delivery. The average age at diagnosis was 10.3 days. Glucose and insulin levels in the critical sample showed an average of 24.7 mg/dL and 26.3 UI/dL. Intravenous infusion of the glucose was greater than 10 mg/kg/min in all cases (M:19,1). Diazoxide was used in 15/25 of the cases, octreotide in 10, glucocorticoid in 8, growth hormone in 3, nifedipine in 2 and glucagon in 1. Ten of the cases underwent pancreatectomy and histology results showed the diffuse form of disease.
Conclusion:
This is the first critic review of a Brazilian sample with congenital HHI.
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