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Related Experiment Video

Updated: May 15, 2026

Real-Time Monitoring of Human Glioma Cell Migration on Dorsal Root Ganglion Axon-Oligodendrocyte Co-Cultures
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Global tracking in human gliomas: a comparison with established tracking methods.

T Nguyen-Thanh1, M Reisert, C Anastasopoulos

  • 1Department of Neuroradiology, University Medical Centre Freiburg, Breisacher St. 64, 79106, Freiburg, Germany, nguyen.thanh.thao@hue-radiology.com.

Clinical Neuroradiology
|January 19, 2013
PubMed
Summary
This summary is machine-generated.

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Cerebral cortex (New York, N.Y. : 1991)·2021

Global tracking (GT) showed robustness in corticospinal tract (CST) detection compared to FACT and PT in glioma patients. GT accurately mapped the CST, even with tissue changes, unlike other methods.

Area of Science:

  • Neuroimaging
  • Neuro-oncology
  • Medical physics

Background:

  • Fibre tractography (FT) methods reconstruct white matter pathways.
  • Global tracking (GT) is a novel FT technique considering all fibres simultaneously.
  • Corticospinal tract (CST) integrity is crucial for motor function and often affected by gliomas.

Purpose of the Study:

  • To compare the efficacy of Global tracking (GT) against Fibre Assignment by Continuous Tracking (FACT) and Probabilistic Tractography (PT).
  • To evaluate the detection rate of the corticospinal tract (CST) in patients with gliomas using these three FT methods.
  • To assess the robustness of GT, FACT, and PT in the presence of pathological changes like edema and tissue disintegration.

Main Methods:

  • CST tractography was performed on 17 glioma patients (8 low-grade, 9 anaplastic astrocytomas) using GT, FACT, and PT.

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  • Diffusion metrics including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were acquired.
  • Tractography methods were validated on a physical phantom to evaluate accuracy and false positive rates.

    • Main Results:

    • Probabilistic tractography (PT) achieved 100% success, Global tracking (GT) 94%, and Fibre Assignment by Continuous Tracking (FACT) 88% in CST detection.
    • Global tracking (GT) demonstrated robustness, accurately mapping the CST even in cases with high AD and RD, indicative of severe tissue changes.
    • Phantom measurements revealed that only GT avoided detecting false positive fibres in areas of fibre crossings.

    Conclusions:

    • Global tracking (GT) is a robust fibre tractography method for corticospinal tract (CST) reconstruction in glioma patients, performing well even with significant tissue abnormalities.
    • Probabilistic tractography (PT) also showed good performance, particularly in areas with increased diffusivity.
    • Fibre Assignment by Continuous Tracking (FACT) was susceptible to decreased diffusivity and susceptibility artifacts, highlighting GT's advantage in challenging clinical cases.