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Updated: May 15, 2026
Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue
Published on: June 21, 2018
Conformational stability of leukocyte lactate dehydrogenase in healthy men of different age
O Yu Fedorenko1, N A Bokhan, S A Ivanova
1Mental Health Research Institute, Siberian division of Russian Academy of Medical Sciences, Tomsk, Russia. f_o_y@mail.ru
Abstract:
Comparative analysis of cytosolic fraction distribution and conformational stability in lactate dehydrogenase (LDH) isozymes in healthy men of different age revealed significant differences indicating age-related characteristics of the enzyme. Activity of cytosolic fraction of LDH-1 and conformational stability of LDH-2 and LDH-3 in 40-year-old men were higher than in 20-year-olds. These data suggest age-related determination of conformational stability of individual LDH isozymes and functional heterogeneity of the enzyme within each isoform.
