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Updated: May 15, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
[A study on the compound bone morphogenetic protein with chitosan and cyanoacrylate on preventive absorption of rat's
Yun Zhang1, Fuqiang Xie, Xin Wang
1Dept. of Stomatology, The Second Hospital, Lanzhou University, Lanzhou 730030, China.
Objective:
To evaluate the effectiveness and feasibility of compound bone morphogenetic protein (BMP) with chitosan and cyanoacrylate on preventive absorption of rat's alveolar ridge.
Methods:
Fifty-four Wistar rats were divided randomly into three groups: Experimental group (compound BMP with chitosan and cyanoacrylate group), control group (chitosan composite group) and blank group. After rat lower incisors were extracted, compound BMP with chitosan and cyanoacrylate were implanted into experimental group rat's residual alveolar fossa, control group implanted with chitosan, blank group left empty. Animals were sacrificed after 3, 6, 9 weeks. X-ray examination, Image-Pro Plus analysis and pathologic observation were evaluated.
Results:
The relative length values of residual alveolar ridge and optical density test in experimental group were all greater than those of control group and blank group at 3, 6, 9 weeks after operation (P < 0.05). Light microscopy showed that new bone formations in experimental group were better than those in control group and blank group at 3, 6, 9 weeks after implantation.
Conclusion:
Compound BMP with chitosan and cyanoacrylate can be used to prevent the absorption of residual alveolar ridge and have more clinical predications. [