Related Experiment Video
Updated: May 15, 2026

A Structured Approach to Extubation in Mechanically Ventilated Rats
Published on: July 18, 2025
Extubation after anaesthesia: a randomised comparison of three techniques
Peter B Richardson1, Sunil Krishnan, Chitra Janakiraman
1University Hospital of Wales, Cardiff, U.K.
Pressure support ventilation may reduce cough severity during awake extubation. This randomized trial compared ventilation modes, finding pressure support ventilation offered advantages over spontaneous and intermittent positive pressure ventilation.
Area of Science:
- Anesthesiology
- Critical Care Medicine
- Respiratory Therapy
Background:
- The optimal ventilation strategy for awake extubation remains uninvestigated.
- Peri-extubation complications can impact patient recovery after anesthesia.
Purpose of the Study:
- To compare spontaneous respiration, intermittent positive pressure ventilation, and pressure support ventilation during awake extubation.
- To evaluate the incidence and severity of peri-extubation complications across different ventilation modes.
Main Methods:
- A randomized controlled trial involving 39 patients undergoing elective surgery.
- Patients were assigned to spontaneous respiration, intermittent positive pressure ventilation, or pressure support ventilation (n=13 each) for awake extubation.
- Complications and hemodynamic parameters were monitored.
Main Results:
- Pressure support ventilation significantly reduced the severity of peri-extubation cough (p=0.049).
- Intermittent positive pressure ventilation resulted in the lowest mean arterial pressure at extubation (p=0.007).
- No significant differences were observed in other complications or time to extubation.
Conclusions:
- Pressure support ventilation may be advantageous for awake extubation, potentially minimizing cough severity.
- Further research is warranted to confirm these findings and optimize extubation strategies.
Related Concept Videos
Endotracheal Tube Extubation
Procedure
Extubation removes the endotracheal tube (ETT) from the patient on mechanical ventilation. It requires a well-coordinated, multidisciplinary approach involving physicians, nurses, respiratory therapists, and other healthcare professionals.
Endotracheal Intubation I: Procedure
The ET tube comprises various components, including a standard adaptor to attach a bag-valve-mask (BVM) or ventilator, a cuff, a pilot balloon, and radiopaque markings along its length to measure the insertion distance. The tube sizes...
Tracheostomy Decannulation
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
Endotracheal Intubation II: Nursing Management
1. Nursing Care of Patients Before Intubation
Before the endotracheal intubation procedure, nurses play an essential role in ensuring the process goes smoothly. The nurses must be familiar with intubation...
Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques
Endoscopic Studies II: Thoracocentesis
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...

