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Related Experiment Video

Updated: May 15, 2026

Intracameral Injection in Rats with Low Risk of Adverse Effects
06:19

Intracameral Injection in Rats with Low Risk of Adverse Effects

Published on: May 31, 2024

Ocular pain after intravitreal injection.

Maria Rosa Sanabria1, Javier A Montero, María Victoria Losada

  • 1Ophthalmology Unit, Palencia Hospital Complex (CAPA), Palencia, Spain.

Current Eye Research
|January 22, 2013
PubMed
Summary
This summary is machine-generated.

Topical tetracaine and lidocaine offer comparable pain relief before intravitreal injections (IVI). Adding diclofenac post-injection did not significantly reduce pain scores in this study.

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Last Updated: May 15, 2026

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Intravitreal Injections in the Ovine Eye
03:37

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Published on: July 5, 2022

Area of Science:

  • Ophthalmology
  • Anesthesiology
  • Pharmacology

Background:

  • Intravitreal injections (IVI) are common ophthalmic procedures.
  • Effective pain management and prevention of post-injection complications are crucial for patient comfort and outcomes.

Purpose of the Study:

  • To compare the efficacy of two anesthetic regimens (tetracaine/naphazoline vs. lidocaine) prior to IVI.
  • To evaluate the effectiveness of two post-injection topical protocols (tobramycin vs. tobramycin/diclofenac) in managing pain and inflammation.

Main Methods:

  • A prospective, randomized, double-masked, comparative study involving 156 patients undergoing IVI.
  • Patients received either tetracaine/naphazoline or lidocaine pre-injection.
  • Post-injection, patients used either tobramycin or tobramycin with diclofenac, with pain assessed using a numerical rating scale.

Main Results:

  • No significant difference in pain scores was observed between tetracaine/naphazoline and lidocaine immediately after IVI (p=0.73).
  • Topical diclofenac did not lead to a significant reduction in pain scores 24 hours post-injection compared to tobramycin alone (p=0.46).
  • Conjunctival hemorrhage was less frequent with topical naphazoline (p=0.055).

Conclusions:

  • Both topical tetracaine and lidocaine provide similar anesthesia for IVI.
  • Topical diclofenac does not appear to offer additional pain relief after intravitreal injections.
  • Naphazoline may help reduce conjunctival hemorrhage post-injection.