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Updated: May 15, 2026
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Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
Published on: August 4, 2018
Rotational thromboelastometry and standard coagulation tests for live liver donors
Maged Mohammed1, Nirmeen Fayed, Ashraf Hassanen
1Department of Anaesthesia, Cairo University, Cairo, Egypt.
Clinical Transplantation
|January 22, 2013
Summary
Standard coagulation tests (SCT) indicated temporary hypocoagulability in liver donors, while rotational thromboelastometry (ROTEM) did not detect this change. Both methods confirmed no hypercoagulability post-donation.
Area of Science:
- Transfusion Medicine
- Hepatobiliary Surgery
- Coagulation Physiology
Background:
- Liver donation surgery involves significant physiological stress.
- Accurate perioperative coagulation monitoring is crucial for patient safety.
- Standard Coagulation Tests (SCT) and Rotational Thromboelastometry (ROTEM) are used to assess hemostasis.
Purpose of the Study:
- To compare coagulation status in live liver donors using SCT and ROTEM.
- To investigate the relationship between SCT and ROTEM findings in this population.
Main Methods:
- A prospective study of 50 right hepatotomy liver donors.
- Coagulation was assessed using ROTEM (EXTEM, INTEM, FIBTEM) and SCT (PT, INR, aPTT, fibrinogen, platelets) perioperatively and up to day 30.
- Analysis focused on detecting hypocoagulability and hypercoagulability.
Main Results:
- SCT revealed temporary hypocoagulability peaking on day one (PT, INR).
- ROTEM parameters remained within normal ranges throughout the study period, showing no hypercoagulability.
- Platelet count significantly correlated with maximum clot firmness in both EXTEM and INTEM assays.
Conclusions:
- ROTEM results did not align with SCT findings regarding temporary hypocoagulability in liver donors.
- Both methods indicated an absence of hypercoagulability.
- Further research with ROTEM may inform updated coagulation monitoring guidelines for liver donors.
