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Contemporary Management Strategies for Peyronie's Disease: A Comprehensive Review.

Yousif M Basheer1, Fatma Ahmed1, Basheer Basheer2

  • 1College of Medicine, Ajman University, Ajman, United Arab Emirates.

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|March 4, 2026
PubMed
Summary

Peyronie's disease (PD) involves penile curvature and pain due to fibrosis. New regenerative treatments like stem cells aim to heal the underlying fibrosis, offering a less invasive approach to PD management.

Keywords:
Peyronie’s diseaseerectile dysfunctionpenile curvaturepenile plaquereview

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Area of Science:

  • Urology
  • Regenerative Medicine

Background:

  • Peyronie's disease (PD) is a fibrotic condition affecting the tunica albuginea, causing penile deformity and pain.
  • It impacts sexual function and leads to significant psychological distress across various age groups.

Purpose of the Study:

  • To review current knowledge on Peyronie's disease epidemiology, risk factors, and natural history.
  • To provide a comprehensive overview of existing and emerging treatments, with a focus on regenerative therapies.

Main Methods:

  • Literature review of Peyronie's disease (PD) research.
  • Analysis of traditional medical, intralesional, and surgical treatments.
  • Evaluation of novel biologic and regenerative therapies, including platelet-rich plasma and stem cells.

Main Results:

  • Traditional treatments for PD are well-established but focus on deformity correction.
  • Emerging regenerative treatments aim to address the underlying fibrotic process in PD.
  • Platelet-rich plasma and stem cell therapies show promise in modifying PD pathology.

Conclusions:

  • Future Peyronie's disease care may integrate regenerative strategies with established options.
  • Individualized, effective, and less invasive treatments are anticipated.
  • Patient-centered counseling is crucial for optimizing PD management outcomes.