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Updated: May 15, 2026
Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology
Published on: March 21, 2018
[The imprint cytology: a tool diagnosis in the operating room]
Gabriela Sofía Gómez-Macías1, Oralia Barboza-Quintana, Juan José Segura-Luna
1Servicio de Anatomía Patológica y Citopatología, Hospital Universitario "Dr. José Eleuterio González," Monterrey, Nuevo León, Mexico. bpositivo66@hotmail.com
Background:
since 1929, the imprint cytology has a great value in the transoperatory as a diagnostic tool and in some cases as an alternate method.
Methods:
during two years period, 416 transoperatory specimens and 384 frozen sections were performed in the Pathology and Cytopathology Department of the University Hospital, "Dr. José E. Gonzalez." Diagnoses were recorded and compared both methods with the final diagnosis given at definitive histological sections. The results were evaluated and p statistics were performed.
Results:
nine of 416 patients (2.2 %) were incorrectly diagnosed by cytology, and 8 of 384 (2.1 %) by frozen section. The diagnostic accuracy for the imprint cytology was 97.8 % and 97.9 % for frozen section. Six of the 416 cases (1.4 %) were misdiagnosed by imprints and frozen sections; the percentage success was 98.5 % using both methods together. The p was statistically significant (0.0005).
Conclusions:
the transoperatory cytology is a fast, easy and inexpensive. It provides morphological detail on intact cells and without the freezing artifacts, so its use as an adjunct to the frozen method is of great value.
