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Lung-Kidney Axis, Aging, and Cell Turnover: Current Evidence and Perspectives.
Adriana Ancer-Arellano1, Yareth Gopar-Cuevas1, María-de-Lourdes Chávez-Briones1
1Department of Pathology, School of Medicine, Autonomous University of Nuevo León, Monterrey 64460, Mexico.
Cells
|May 27, 2026
Summary
Aging causes cellular dysfunction, particularly in the lungs and kidneys. Senescent cells release signals, creating a damaging feedback loop that worsens age-related lung and kidney diseases.
Area of Science:
- Gerontology
- Cellular Biology
- Organ Physiology
Background:
- Aging drives cellular dysfunction and disease.
- Lungs and kidneys are susceptible to age-related damage due to high exposure to stressors.
- A bidirectional communication axis exists between the lungs and kidneys.
Purpose of the Study:
- To propose a mechanistic framework linking cell turnover alterations in the lung-kidney axis during aging.
- To explore how age-related cellular changes contribute to organ dysfunction.
- To understand the feedback loops exacerbating lung and kidney diseases.
Main Methods:
- Literature review and synthesis.
- Analysis of age-related cellular changes, including senescence and apoptosis.
- Examination of the senescence-associated secretory phenotype (SASP) and its role.
Main Results:
- Age-related cellular changes induce cellular senescence, characterized by cell cycle arrest and telomere shortening.
- Senescent cells develop a SASP, releasing mediators that transmit damage signals.
- These processes establish a pathological feedback loop between the lungs and kidneys.
Conclusions:
- Aging promotes a bidirectional axis of damage between the lungs and kidneys.
- Cellular senescence and SASP contribute to age-related organ dysfunction.
- This framework highlights increased susceptibility to lung and kidney diseases in aging individuals.
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