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Simulation of Human Identification Using DNA From Formalin-Fixed and Paraffin-Embedded (FFPE) Cancer Tissue as a
Marta Ortega-Martínez1, María-de-Lourdes Chávez-Briones1, Mariana Moreno-Mares1
1Department of Pathology, School of Medicine, Autonomous University of Nuevo León, Monterrey, MEX.
Cureus
|December 15, 2025
Summary
Formally fixed, paraffin-embedded (FFPE) cancerous tissue slides can aid in identifying human remains. While complete genetic profiles were obtained from cancerous FFPE samples, allele loss in healthy or mixed tissues requires caution during identification.
Area of Science:
- Forensic Science
- Molecular Biology
- Histopathology
Background:
- Archived formalin-fixed, paraffin-embedded (FFPE) tissues are crucial for DNA-based identification of deceased individuals.
- Malignant tumor FFPE tissues present unique challenges for genetic identification due to potential DNA alterations.
Keywords:
cancerdna analysisforensic scienceformalin-fixed and paraffin-embedded (ffpe) tissueshuman remains identification
