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Updated: May 15, 2026

Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract

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Published on: November 28, 2012

Radiation cataract: clinicopathologic report.

Mehrdad Mohammadpour¹, Zahra Ebadi Movahedan, Mahmoud Jabbarvand

¹Ophthalmology Department and Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. mahammadpour@yahoo.com

Journal of Cataract and Refractive Surgery

|January 22, 2013

Summary

Radiation therapy can cause significant eye complications, including cataracts and anterior capsule fibrosis, years after treatment. Successful cataract surgery restored vision to 20/20, demonstrating effective treatment for radiation-induced ocular damage.

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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

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Published on: September 20, 2018

Area of Science:

Ophthalmology
Radiation Oncology
Pathology

Background:

This study presents a case report on a patient with a history of intensive radiation therapy.
No financial or proprietary interests were disclosed by the authors.

Observation:

A 52-year-old woman developed bilateral anterior and posterior subcapsular cataracts.
Anterior capsule fibrosis was noted 12 years post-radiation exposure.
The patient underwent uneventful cataract surgery.

Findings:

Post-surgery, the patient achieved 20/20 corrected distance visual acuity in both eyes.
Histopathological analysis (Hematoxylin-eosin staining) of the anterior capsule showed significant subcapsular scar formation.
Evidence of fibroblast proliferation was observed in the scar tissue.

Implications:

This case highlights the potential for delayed ocular complications following radiation therapy.
It underscores the effectiveness of cataract surgery in managing radiation-induced visual impairment.
The findings contribute to understanding the pathological mechanisms of radiation-induced ocular fibrosis.