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Updated: May 15, 2026

Identifying Protein-protein Interaction Sites Using Peptide Arrays
07:44

Identifying Protein-protein Interaction Sites Using Peptide Arrays

Published on: November 18, 2014

Peptidomics methods for the identification of peptidase-substrate interactions

Anna Mari Lone1, Yun-Gon Kim, Alan Saghatelian

  • 1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.

Current Opinion in Chemical Biology
|January 22, 2013
PubMed
Summary

Peptidomics approaches identify bioactive peptide substrates and the peptidases that regulate them. This advances understanding of physiological signaling and aids in discovering new drug targets for peptide regulation.

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Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
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