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Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
Published on: January 21, 2018
[Environmental pollution and allergy: immunological mechanisms].
1Inserm U1019, CNRS UMR 8204, pulmonary immunity, center for infection and immunity of Lille, institut Pasteur de Lille, université Lille Nord de France, 1, rue du Prof.-Calmette, BP 245, 59019 Lille, France.
Revue De Pneumologie Clinique
|January 22, 2013
Summary
Airborne pollutants like diesel exhaust and ozone worsen allergies by causing inflammation and skewing immune responses. Genetic and epigenetic factors influence how these environmental factors amplify allergic reactions through oxidative stress.
Area of Science:
- Environmental Science
- Immunology
- Toxicology
Context:
- Airborne pollutants are significant environmental factors in allergic sensitization and disease.
- Particulate matter's effects depend on particle characteristics, chemical content, and host genetics.
- Diesel exhaust and ozone are known to increase inflammation and promote allergic immune responses.
Purpose:
- To explore the mechanisms by which airborne pollutants influence allergic sensitization and disease expression.
- To investigate the role of oxidative stress, genetic susceptibility, and epigenetic factors in pollutant-induced allergic reactions.
Summary:
- Airborne pollutants, including particulate matter and gases like ozone, promote allergic sensitization and disease.
- These pollutants can exacerbate inflammation and act as adjuvants, shifting immune responses towards a Th2 phenotype.
- Pollutant-induced amplification of allergic reactions is linked to oxidative stress, influenced by genetic and epigenetic factors.
Impact:
- Understanding these mechanisms is crucial for developing strategies to mitigate the impact of air pollution on allergic diseases.
- Highlights the interplay between environmental exposures, genetic predisposition, and immune system dysregulation in allergy development.
- Provides insights into potential therapeutic targets for managing pollution-exacerbated allergies.
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