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Related Experiment Videos

Estrous cycle irregularities in overfed rats.

Z Glick1, S Yamini, J Lupien

  • 1Geriatric, Research Education and Clinical Center, Veterans Administration Medical Center, Sepulveda, CA 91343.

Physiology & Behavior
|February 1, 1990
PubMed
Summary

Overfeeding in rats led to irregular estrous cycles, potentially due to increased brown adipose tissue (BAT) thermogenesis. Restoring a normal diet corrected these reproductive cycle disruptions.

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Area of Science:

  • Reproductive Endocrinology
  • Metabolic Physiology
  • Animal Models of Obesity

Background:

  • Obesity in rodents often correlates with reproductive dysfunction, but the exact causes remain unclear due to associated metabolic disturbances.
  • Existing animal models for obesity-induced reproductive issues are confounded by metabolic abnormalities.

Purpose of the Study:

  • To investigate the relationship between diet-induced obesity, brown adipose tissue (BAT) thermogenesis, and estrous cycle regularity in metabolically intact rats.
  • To determine if increased BAT thermogenesis during overfeeding contributes to reproductive impairments.

Main Methods:

  • Rats were fed either a cafeteria-type diet (obesity group) or standard Purina chow (control group).
  • Body weight, caloric intake, and estrous cycle length were monitored.

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  • Brown adipose tissue (BAT) thermogenesis was assessed in relation to dietary intake and reproductive parameters.

    • Main Results:

    • Cafeteria feeding resulted in hyperphagia, increased body weight, and prolonged estrous cycles, primarily due to a longer diestrous phase.
    • Increased brown adipose tissue (BAT) thermogenesis was observed in cafeteria-fed rats.
    • Switching back to a standard diet normalized caloric intake, body weight, and estrous cycle regularity.

    Conclusions:

    • Diet-induced obesity in rats is associated with disruptions in the estrous cycle.
    • Increased brown adipose tissue (BAT) thermogenesis during overfeeding may be a key factor contributing to reproductive cycle irregularities.
    • Reproductive function appears to be sensitive to changes in body temperature regulated by BAT thermogenesis.