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Updated: May 15, 2026

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Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
Published on: March 20, 2015
Surface-enhanced Raman spectroscopy with monolithic nanoporous gold disk substrates.
Ji Qi1, Pratik Motwani, Mufaddal Gheewala
1Department of Electrical and Computer Engineering, University of Houston, 4800 Calhoun Road, Houston, Texas 77204, USA.
Nanoscale
|January 22, 2013
Summary
Researchers fabricated tiny gold disks with nanopores using hybrid methods. These disks achieved a high surface-enhanced Raman scattering signal, demonstrating their potential for sensitive chemical detection.
Area of Science:
- Nanotechnology
- Materials Science
- Surface Chemistry
Background:
- Surface-enhanced Raman scattering (SERS) is a powerful technique for detecting molecules at low concentrations.
- Developing novel nanostructures with enhanced optical properties is crucial for improving SERS sensitivity.
- Hierarchical nanoporous gold (hNPG) offers unique plasmonic properties for SERS applications.
Purpose of the Study:
- To fabricate monolithic hierarchical nanoporous gold disks with controlled dimensions.
- To evaluate the SERS performance of individual hNPG disks.
- To demonstrate the potential of hNPG disks for sensitive molecular detection.
Main Methods:
- Fabrication of monolithic hNPG disks (500 nm diameter, 75 nm thickness, 3.5 nm pore radius) using hybrid processes.
- Characterization of the nanostructure morphology and dimensions.
- SERS measurements using benzenethiol self-assembled monolayer and 785 nm laser excitation.
Main Results:
- Successfully fabricated monolithic hNPG disks with precise control over size and porosity.
- Achieved a SERS enhancement factor of at least 10^8 on individual hNPG disks.
- Demonstrated strong and reproducible SERS signals from benzenethiol molecules.
Conclusions:
- Monolithic hNPG disks are effective SERS substrates with ultra-high enhancement factors.
- The hybrid fabrication process enables the creation of tailored nanostructures for plasmonic applications.
- These hNPG disks show significant promise for highly sensitive chemical sensing and molecular analysis.

